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A final combination of note involves co-administering immune checkpoint blocking reagents with anti-angiogenic therapies; this combination is based on data showing that tumor-infiltrating blood vessels are disordered and represent a challenge to T cell egress. Normalizing the tumor vasculature with anti-VEGF targeted antibodies may facilitate tumor infiltration with T cells, and be synergistic with immune checkpoint blockade. Preliminary data suggest activity for the combination of anti-VEGF (Bevicizumab) and anti-PD-L1 (Atezolizumab) in RCC, with an interesting Phase II trial in (NCT01984242) now fully accrued. So, taken together, both preclinical and clinical data support the notion that combined immune checkpoint blockade may be required to induce durable andor complete responses in the majority of NMIBC patients, but also highlight the fact that the ever expanding number of potential combinations means that clinical evaluation could prove challenging. RADIATION INDUCED IMMUNE RESPONSES. Andrew Sharabi, M.

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