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The GLUT family is a transmembrane protein which has 12 transmembrane domains with both amino and carboxy-terminal ends exposed to the cytoplasmic side of the plasma membrane. GLUT1 is found at variable levels in many tissues, while GLUT3 and GLUT4 are expressed in a tissue-specific manner (65, 70). Increased expression of GLUT1 has been shown in various types of cancers including hepatic, pancreatic, breast, esophageal, brain, renal, lung, cutaneous, colorectal, endometrial, ovarian and cervical carcinoma. (71-80).

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