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Recently performed phase I clinical trial (NCT00096707) for 2-DG-treatment on several types of cancer patients showed that 2-DG exhibited positive responses in patients who were treated orally with this compound. These data support our continuing hope that 2DG serves as a lead compound to develop a better drug to target glycolytic pathway for cancer therapy. In addition, the results of phase III clinical trials have shown that the combination of 2-DG and x003b3;-radiation was well tolerated in cerebral glioma patients (65). Therefore, such combination therapies by taking advantage of the dependence of cancer cells on glycolysis may also be a promising approach for cancer treatment.

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