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Both immunotherapy drugs and novel tyrosine kinase inhibitors are given systemically rather than by an intravesical route. Therefore, expertise is needed in both administration and management of unique toxicities and clinical trials will require enhanced collaborations between urologists and medical oncologists. These first-generation trials will need to extend our biological understanding of these new drugs in urothelial cancer and thus will require enhanced collaborations between physicians and translational scientists to establish sustainable research platforms for subsequent trials. Our charge to the participants of the clinical trial planning meeting is to spur the development of two separate trial concepts to be exploited in the cooperative group mechanisms.

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