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Furthermore, these cells were shown to be tumorigenic as well as angiogenic in nude mice, suggesting that G6PD acts as oncogene. The higher rate of glycolysis in cancer cells generates increased number of metabolites such as hydrogen ions and lactate that cause acidification of the cells. Although acidosis can stimulate invasion, migration, mutagenesis, and radioresistance in cancer cells, it also causes apoptosis through the p53 pathway (1, 95).]