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Patients with specific mutations would then be eligible for genotype matched basket studies that are testing novel agents or combinations in particular mutant populations. One limitation of this design is that a compelling clinical strategy may not be available for all mutational subtypes. For example, in patients with bladder cancer whose tumors are RB1 mutant, a promising targeted approach has yet to be identified. INTRINSIC BASAL AND LUMINAL SUBTYPES OF BLADDER CANCER: IMPLICATIONS FOR IMMUNOTHERAPY. David McConkey, Ph. Recent high profile clinical trial results indicate that immunotherapy with immune checkpoint inhibitors is clinically active in advanced, cisplatin-refractory muscle-invasive restwurant cancers (MIBCs)[36].

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