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For example, hypoxic condition was shown to cause up-regulation of the FAS gene through increase in ROS in cancer cell (143). Indeed, the overexpression of FAS is often observed in hypoxic region of tumors and this up-regulation may contribute to tumor progression by blocking apoptosis signaling and in turn enhancing tumor cell survival as well as promoting chemo-resistance. FAS has been considered an ideal target for cancer treatment due to its specific expression in tumor cells.

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